前列地尔脂微球注射液临床超说明书用药干预分析
投稿时间:2018-03-30  修订日期:2018-06-12  点此下载全文
引用本文:曹爱霖,唐彦玲,钱皎,王卓.前列地尔脂微球注射液临床超说明书用药干预分析[J].药学实践杂志,2018,36(5):475~478
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作者单位E-mail
曹爱霖 第二军医大学附属长海医院药学部, 上海 200433  
唐彦玲 第二军医大学附属长海医院药学部, 上海 200433  
钱皎 第二军医大学附属长海医院药学部, 上海 200433  
王卓 第二军医大学附属长海医院药学部, 上海 200433 wangzhuo088@163.com 
基金项目:国家临床重点专科军队建设项目(临床药学);上海市重要薄弱学科建设项目(2016ZB0303-01)
中文摘要:目的 调查第二军医大学附属长海医院前列地尔脂微球注射液的应用情况,分析其临床应用合理性,评价医院行政干预在促进临床合理用药中的作用。方法 以2016年7月28日医院行政干预为界限,对2016年7月和8月共计1 351例使用本品的患者,统计其所在科室、临床诊断、前列地尔的用法用量。结果 本品在医院各科室广泛应用,65.41%的病例出现了超适应证用药的情况,99.85%的病例存在超说明书用法用量的情况,0.39%的病例出现了禁忌证用药的情况,医院行政干预前后结果近乎一致。结论 超说明书应用本品的情况在临床广泛存在,应当引起临床重视,仅实施行政干预的效果较差。
中文关键词:前列地尔  合理用药  医嘱点评
 
Interventional analysis on the off-label drug use of alprostadil lipid microsphere injection
Abstract:Objective To investigate the application of Lipo-PEG1 injection in our hospital, analyze the rationality of its clinical application and evaluate the role of the administrative intervention in promoting the rational drug use in the hospital. Methods Based on the administrative guidelines announced on July 28, 2016, the data from 1 351 patients who received Lipo-PEG1 injection during July and August were collected and analyzed. Results Lipo-PEG1 injection is widely used in different departments at the hospital. 65.41% cases received this medication as off-label indications. 99.85% cases used this drug with impropriate dosage and indications. 0.39% cases had contraindications. There was no difference before and after the administrative intervention. Conclusion The off-label use of Lipo-PEG1 injection is very common in clinical practice. More clinical attention should be paid to this problem. The results from simple administrative intervention is unsatisfied.
keywords:Lipo-PEG1  rational drug use  comment on medical order
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