盐酸美金刚改善缺血性脑卒中患者神经认知功能的回顾性研究
投稿时间:2018-05-23  修订日期:2018-06-27  点此下载全文
引用本文:杨世畅,何荆贵,周素月,李雪梅.盐酸美金刚改善缺血性脑卒中患者神经认知功能的回顾性研究[J].药学实践杂志,2018,36(5):457~460
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作者单位
杨世畅 解放军总医院, 北京 100853 
何荆贵 解放军总医院, 北京 100853 
周素月 解放军总医院, 北京 100853 
李雪梅 解放军总医院, 北京 100853 
基金项目:科技部重点课题(2017YFC1307700);军队保健专项课题(17BJZ39)
中文摘要:目的 探讨盐酸美金刚(简称"美金刚")改善缺血性脑卒中患者神经认知功能的效果。方法 对2016年6月至12月于解放军总医院干部诊疗科进行治疗的缺血性脑卒中患者进行回顾性研究,根据其是否规律服用美金刚,分为美金刚组和非美金刚组,对两组患者的年龄、性别、BMI、随访时间及神经认知功能评分进行统计,神经认知功能评分采用蒙特利尔认知评估量表(MoCA)。结果 两组患者的年龄、BMI、随访时间均无明显差异。初诊时,美金刚组MoCA评分(19.19±3.23),非美金刚组评分(18.47±3.03),P=0.651;2周时,美金刚组(21.06±2.62),非美金刚组(19.19±2.87),P=0.038;4周时,美金刚组(23.50±2.00),非美金刚组(21.30±2.16),P=0.002;末次随访时,美金刚组(24.69±2.09),非美金刚组(23.22±2.08),P=0.031。结论 美金刚可有效改善缺血性脑卒中患者的神经认知功能。
中文关键词:盐酸美金刚  缺血性脑卒中  神经认知功能  蒙特利尔认知评估量表
 
The retrospective study of the improvement of memantine hydrochloride on neurocognitive function in patients with ischemic stroke
Abstract:Objective To investigate the effect of memantine hydrochloride on improving neurocognitive function in patients with ischemic stroke. Methods Patients with hemorrhagic stroke who were treated in the officer consultation department of General Hospital of PLA from June to December 2016 were retrospectively studied. According to whether or not they were taking memantine, the patients were divided into the memantine group and the control group. The data including age, sex, BMI, follow-up time, the neurocognitive function score were collected. The neurocognitive function score was assessed by the Montreal Cognitive Assessment Scale (MoCA). Results There was no significant difference in age, BMI, and follow-up time between the two groups. The MoCA score was(19.19±3.23) in memantine group, (18.47±3.03) in control group, P=0.651;(21.06±2.62)in memantine group,(19.19±2.87) in control group,P=0.038 at 2 weeks;(23.50±2.00) in memantine group,(21.30±2.16) in control group,P=0.002 at 4 weeks;At the last follow-up, memantine group was(24.69±2.09), control group was (23.22±2.08), P=0.031. Conclusion Memantine could effectively improve neurocognitive function in patients with ischemic stroke.
keywords:memantine hydrochloride  ischemic stroke  neurocognitive function  Montreal Cognitive Assessment Scale
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