超重可能是急性高山病的危险因素:一项Meta分析
投稿时间:2018-03-20  修订日期:2018-07-03  点此下载全文
引用本文:熊娟,鹿辉,王荣,贾正平.超重可能是急性高山病的危险因素:一项Meta分析[J].药学实践杂志,2018,36(5):433~437
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作者单位E-mail
熊娟 兰州总医院药剂科, 甘肃 兰州 730050  
鹿辉 兰州总医院药剂科, 甘肃 兰州 730050  
王荣 兰州总医院药剂科, 甘肃 兰州 730050  
贾正平 兰州总医院药剂科, 甘肃 兰州 730050 jiazhengpinglzzyy@163.com 
基金项目:全军后勤科研项目(CWH17J012);国家自然科学基金资助(81401552)
中文摘要:目的 超重也许是急性高山病(acute mountain sickness,AMS)的危险因素,但仍存在很多争议。因此,进行Meta分析研究超重在AMS发生中的作用。方法 利用电子数据库系统检索研究超重与AMS相关性的文献(截至2018年2月28日)。利用Mantel-Haenszel随机效应模型进行数据整合。纳入文献的异质性由I2的值表示。以P<0.05为具有显著性差异。用Revman 5.0软件处理和分析数据,结果以95%置信区间森林图的形式表示。结果 纳入研究的566名超重志愿者中有300名患AMS(53%),而1 006名非超重志愿者中只有338名患AMS(34%),超重志愿者患AMS的危险比率(risk ratio,RR)为2.02(95% CI 1.08~3.76,Z=2.21,P=0.03)。结果表明超重是AMS发生的一项危险因素。结论 虽然需要进一步深入的研究来确认超重在AMS发生中的作用,但根据有限的研究提示,超重也许是AMS发生的危险因素。因此,超重个体在进入高海拔地区前,应当做好充分的预防措施来避免AMS的发生。
中文关键词:超重  急性高山病  荟萃分析
 
Overweight might be a risk factor of acute mountain sickness: a Meta-analysis
Abstract:Objective Overweight might be a risk factor of acute mountain sickness (AMS) but its efficacy on developing AMS remained controversial. To study the role of overweight in AMS by a Meta-analysis. Methods A comprehensive literature search (last update, February 28th 2018) was carried out by searching electronic databases for full texts of studies which compared incidence of AMS in overweight with non-overweight individuals. The primary outcome measure for this meta-analysis was the incidence of AMS. Mantel-Haenszel random effect model was used to aggregate data. Heterogeneity of included trials was interpreted by I2 values. A α level of 0.05 was used as the level of significance. The results were reported in a forest plot with 95% CI. Revman 5.0 software provided by the Cochrane Collaboration was used for data processing and analysis. Results AMS occurred in 300 of 566 (53%) in overweight individuals and in 338 of 1 006 (34%) in non-overweight individuals. Compared with non-overweight individuals and independent of the baseline risk ratio (RR), the combined RR of developing AMS in overweight individuals was 2.02 (95% CI 1.08 to 3.76, Z=2.21, P=0.03). It was suggested that obese was a risk factor for developing AMS. The five included studies had high heterogeneity (I2=94%). Conclusion Although further in-depth studies were needed to confirm the function of overweight in the development of AMS, according to a limited number of studies, overweight might be a risk factor of AMS. Therefore, overweight individuals should be provided adequate prophylaxis against AMS before ascent to high altitude.
keywords:overweight  acute mountain sickness  Meta-analysis
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