多奈哌齐联合美金刚治疗阿尔茨海默病的有效性及安全性系统评价
投稿时间:2017-07-27  修订日期:2018-02-10  点此下载全文
引用本文:万素馨,向毅,罗亚玲.多奈哌齐联合美金刚治疗阿尔茨海默病的有效性及安全性系统评价[J].药学实践杂志,2018,36(3):260~264,281
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作者单位E-mail
万素馨 重庆三峡中心医院, 重庆 404000  
向毅 重庆三峡中心医院, 重庆 404000  
罗亚玲 重庆医科大学医学信息学院数学教研室, 重庆 400016 315093932@qq.com 
基金项目:中国社会科学基金(15BGL191)
中文摘要:目的 采用系统评价的方法评估多奈哌齐联合美金刚治疗阿尔兹海默病(AD)的有效性和安全性,为临床用药提供参考。方法 全面检索中国知网、万方、维普、中国生物医学文献等数据库,收集2014—2016年的相关文献,按纳入和排除标准进行文献筛选,采用Jadad量表进行质量评价,并用RevMan5.3软件进行数据处理。结果 18篇文献纳入本系统评价,均为随机对照研究,样本量1 796例(研究组900例,对照组896例)。研究组的简易精神状态量表(MMSE)、神经精神问卷(NPI)、痴呆病理行为评定量表(BEHAVE-AD)评价结果优于对照组,而日常生活功能量表(ADL)和阿尔茨海默病评价量表认知部分(ADAS-Cog)方面与对照组没有显著差异。结论 研究组患者的精神状态、病理行为等方面有明显改善,治疗效果优于对照组。在临床应用中,应根据不同患者的具体病情来考虑用药方案。
中文关键词:多奈哌齐  美金刚  阿尔兹海默病  系统评价
 
The efficacy and safety evaluation of donepezil combined with memantine for the treatment of Alzheimer's disease
Abstract:Objective To evaluate the efficacy and safety of donepezil combined with memantine in the treatment of Alzheimer's disease and provide a guidance for the proper clinical use of those medications. Methods The literatures published from 2014 to 2016 in CNKI/VIP/WanFang Med-online/CBM and other databases were collected. Screening and quality evaluation were carried out with include and exclude standard. The software RevMan 5.3 was used for data analysis. Results Eighteen studies included are randomized controlled trials with 900 cases in study group and 896 cases in control group. The combined results showed that MMSE, NPI and BEHAVE -AD of the combination therapy were superior to those of monotherapy group. There is no significant difference in ADL and ADAS-Cog. Conclusion The combination therapy was better than monotherapy both in mental state and pathological behavior. The clinical application of those medications should be based on the specific conditions of individual patient.
keywords:donepezil  memantine  Alzheimer's disease  systematic review
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