抑郁症致病机制及中药治疗抑郁症的机制研究
投稿时间:2017-12-19  修订日期:2018-01-22  点此下载全文
引用本文:姚媛,周艺,周婷婷.抑郁症致病机制及中药治疗抑郁症的机制研究[J].药学实践杂志,2018,36(3):193~197
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作者单位E-mail
姚媛 安徽中医药大学药学院, 安徽 合肥 230012
第二军医大学药学院, 上海 200433
上海市药物(中药)代谢产物研究重点实验室, 上海 200433 
 
周艺 94826部队医院内科, 上海 200433  
周婷婷 第二军医大学药学院, 上海 200433
上海市药物(中药)代谢产物研究重点实验室, 上海 200433 
tingting_zoo@163.com 
基金项目:国家自然科学基金资助项目(81573584,81773862)
中文摘要:抑郁症严重危害人类身心健康,世界卫生组织预测:2020年抑郁症将成为非正常死亡和残疾的第二大原因。目前临床上大多使用三环类抗抑郁药(TCA)、四环类抗抑郁药、选择性5-HT再摄取抑制药等来治疗抑郁症,但长期应用这类药物易产生耐药性,不良反应明显,且这种通过单一成分阻断特定单一靶点的药物,对于涉及体内多个系统的生物学异常往往难以达到治疗效果。中药组方通过其所包含的多组分能同时调节多靶点、调节疾病网络的多个环节,在获得较高疗效的同时可降低化学药单靶点引起的毒副作用,且目前国内外对一些传统中药抗抑郁作用机制的研究报道也日渐增多,主要集中在神经递质水平释放、海马脑源性神经营养因子(BDNF)表达及细胞因子等方面。此外,最新的研究认为肠道菌群可能参与了从情感性疾病到神经系统疾病的发生发展。综述近年来中药抗抑郁神经保护作用的机制研究进展,以期为抑郁症发病机制探讨及抗抑郁药物研究提供借鉴和指导。
中文关键词:中药  抑郁症  机制  神经营养因子  炎症介质  脑-肠-微生物轴
 
Pathogenesis of depression and the mechanism research in TCM treatment of major depression
Abstract:Depression is a serious health hazard and the World Health Organization predicts that depression will be the second leading cause of abnormal death and disability by 2020. Currently, most antidepressants are tricyclic antidepressants (TCA), tetracyclic antidepressants and selective 5-HT reuptake inhibitors. Long term use of those medications will develop resistance and adverse reactions. In addition, drugs that block a single target are often hard to achieve therapeutic outcomes due to the biological abnormalities involving multiple systems in the body. Traditional Chinese Medicine (TCM) can simultaneously act on multiple targets to influence the disease network in many aspects at the same time. This approach has higher efficacy and lower side effects than a single chemical medication. Recently, there are increasing numbers of research papers on antidepressant mechanism of TMC, mainly focused on the release level of neurotransmitters, hippocampus brain derived neurotrophic factor (BDNF) expression and cytokines, etc. The latest researches also indicated that the gut microbiota has involved the development of emotional diseases and the diseases related to central nerves system. This paper reviews the mechanism studies of TMC as antidepressants and neuroprotection agents in order to shed new light on the study of depression pathogenesis and development of new antidepressant medications.
keywords:Traditional Chinese Medicine  depression  mechanism  neurotrophic factor  inflammatory mediators  microbiota-gut-brain axis
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