皮肤病专科医院302例药品不良反应报告分析
投稿时间:2017-10-25  修订日期:2017-12-29  点此下载全文
引用本文:信如娟,潘会君,李莹,安多朋,朱全刚.皮肤病专科医院302例药品不良反应报告分析[J].药学实践杂志,2018,36(2):186~188,191
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信如娟 上海市皮肤病医院药剂科, 上海 200443  
潘会君 上海市皮肤病医院药剂科, 上海 200443  
李莹 上海市皮肤病医院药剂科, 上海 200443  
安多朋 上海市皮肤病医院药剂科, 上海 200443  
朱全刚 上海市皮肤病医院药剂科, 上海 200443 qgzhu@126.com 
基金项目:中央高校基本科研业务费专项资金(1501219169);上海市科学技术委员会科研计划项目课题(17401901800)
中文摘要:目的 探讨上海市皮肤病医院药品不良反应(ADR)的特点及规律,为临床合理、安全用药提供依据。方法 对该院门诊和住院病房2015年9月至2017年9月上报的302例ADR报告采用回顾性分析,对患者性别、年龄、药品种类及构成比、给药途径、ADR累及系统/器官及临床表现等进行统计、汇总和分析。结果 302例ADR报告中,女性(54.6%)高于男性(45.4%)。抗感染药物ADR居多,占27.8%。引发ADR的给药途径以口服和静脉滴注为主,其构成比分别为70.2%和24.8%。ADR累及系统/器官主要涉及皮肤及其附件损害(61.6%)和消化系统(15.9%)。结论 ADR的发生与诸多因素有关,临床应重视和加强ADR监测,严格掌握药物使用的适应症,以降低ADR的发生率。
中文关键词:药品不良反应  报告  分析  合理用药
 
302 cases of adverse drug reaction reports
Abstract:Objective To study the features, general patterns and predisposing factors of adverse drug reactions (ADR) occurred in our hospital and to provide the guidance for rational and safe use of drugs in clinic. Methods 302 cases of ADR were reported from September 2015 to September 2017 in our hospital. Age distribution, gender, route of administration, drug categories, systems or organs involved, clinical manifestations, adverse reaction types involved in ADRs were analyzed retrospectively. Results Among the 302 ADR reports, 137 cases are male patients (accounting for 45.4%) and 165 cases were female patients (accounting for 54.6%). 27.8% of ADR was related to anti-infective agents. 70.2% of ADR came from oral administration and 24.8% ADR was due to intravenous administration. The main clinical manifestations of ADR were lesion of skin and its appendants (61.6%) and followed by the digestive system injury (15.9%). Conclusion The multiple factors may lead to high frequency of ADR. In order to promote rational drug use and reduce the occurrence of ADR, clinicians should pay attention to the ADR monitoring and strictly follow the clinical indications of medications.
keywords:adverse drug reaction  report  analysis  rational drug use
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