粒细胞巨噬细胞刺激因子联合全肺灌洗对特发性肺泡蛋白沉积症的疗效和安全性
投稿时间:2017-05-29  修订日期:2017-12-07  点此下载全文
引用本文:刘国栋,周丽,张文静,王卓.粒细胞巨噬细胞刺激因子联合全肺灌洗对特发性肺泡蛋白沉积症的疗效和安全性[J].药学实践杂志,2018,36(2):183~185
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作者单位E-mail
刘国栋 解放军477医院, 湖北 襄阳 441003
第二军医大学附属长海医院, 上海 200433 
 
周丽 解放军477医院, 湖北 襄阳 441003  
张文静 第二军医大学附属长海医院, 上海 200433 zhangwenjingahmu@163.com 
王卓 第二军医大学附属长海医院, 上海 200433  
中文摘要:目的 观察粒细胞巨噬细胞刺激因子(GM-CSF)联合全肺灌洗治疗特发性肺泡蛋白沉积症(IPAP)的疗效和安全性。方法 选取2015年8月至2017年3月在第二军医大学附属长海医院就诊的2例IPAP患者,经全肺灌洗后,分别予皮下注射和雾化吸入GM-CSF治疗,观察其疗效和安全性。结果 2例患者经GM-CSF联合全肺灌洗治疗,病情缓解。结论 GM-CSF联合全肺灌洗治疗对IPAP患者治疗有效、用药安全。
中文关键词:肺泡蛋白沉积症  全肺灌洗  粒细胞巨噬细胞刺激因子  治疗效果
 
Effectiveness and safeness of granulocyte macrophage colony stimulating factor and whole lung lavage therapy in idiopathic pulmonary alveolar proteinosis
Abstract:Objective To observe the effectiveness and safeness of granulocyte macrophage colony stimulating factor(GM-CSF) and whole lung lavage therapy for patients with idiopathic pulmonary alveolar proteinosis (IPAP). Methods Two IPAP patients who were hospitalized in Changhai Hospital from August 2015 to March 2017 were enrolled for the study. Both patients were treated with GM-CSF therapy after whole lung lavage. One patient received GM-CSF by subcutaneous injection and the other by inhalation. Results Both patients' conditions were improved after GM-CSF and whole lung lavage therapy. Conclusion Treatment with subcutaneous injection or inhalation of granulocyte macrophage colony stimulating factor and whole lung lavage is safe and effective for IPAP patients.
keywords:pulmonary alveolar proteinosis  whole lung lavage  granulocyte macrophage colony stimulating factor  treatment outcome
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