比较万古霉素持续输注与间断输注引起肾毒性的荟萃分析
投稿时间:2017-06-30  修订日期:2017-09-28  点此下载全文
引用本文:郑丽丽,轩辕欢,姜倩,范芳芳,姚莉,赵生俊.比较万古霉素持续输注与间断输注引起肾毒性的荟萃分析[J].药学实践杂志,2018,36(2):136~139,146
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作者单位E-mail
郑丽丽 新疆医科大学附属中医医院药学部, 新疆 乌鲁木齐 830054  
轩辕欢 新疆医科大学附属中医医院药学部, 新疆 乌鲁木齐 830054  
姜倩 新疆医科大学附属中医医院药学部, 新疆 乌鲁木齐 830054  
范芳芳 新疆医科大学附属中医医院药学部, 新疆 乌鲁木齐 830054  
姚莉 新疆医科大学附属中医医院药学部, 新疆 乌鲁木齐 830054  
赵生俊 新疆医科大学附属中医医院药学部, 新疆 乌鲁木齐 830054 1519531677@qq.com 
基金项目:国家自然科学基金(81460603)
中文摘要:目的 比较万古霉素两种给药方式(持续输注与间断输注)引起的肾毒性。方法 计算机检索Embase、PubMed、The Cochrane Register of Controlled Trials和CBM、CNKI、万方数据库。采用Cochrane协作网提供的Revman5.2软件进行Meta分析。结果 共纳入2篇随机对照试验(RCT)和8篇观察性研究,共纳入患者1 764例,其中持续输注1 037例,间断输注727例。持续输注与间断输注引起的肾毒性发生率无显著性差异(P>0.05)。结论 万古霉素持续输注较间断输注不能有效降低肾毒性的发生率。
中文关键词:万古霉素  持续输注  间断输注  肾毒性  荟萃分析
 
Meta-analysis on renal toxicity of vancomycin given by continuous infusion vs intermittent infusion
Abstract:Objective To compare the renal toxicity of vancomycin with continuous infusion vs intermittent infusion. Methods The databases of EMBASE, PUBMED, the Cochrane Register of Controlled Trials, CBM, CNKI and WanFang were searched. The Cochrane Revman5.2 software was used for Meta-analysis. Results Two RCTs and eight observational studies were included in the systematic literature search with total of 1 764 patients. 1 037 patients received vancomycin with continuous infusion while 727 patients with intermittent infusion. The Meta-analysis indicated that there was no significant difference in renal toxicity between continuous infusion group and intermittent infusion group(P>0.05). Conclusion Vancomycin continuous infusion cannot effectively reduce the incidence of renal toxicity.
keywords:vancomycin  continuous infusion  intermittent infusion  renal toxicity  Meta-analysis
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