ACEI联合醛固酮受体拮抗剂对高血压肾病患者Cys-C及尿微量蛋白的调节作用
投稿时间:2017-11-05  修订日期:2017-12-25  点此下载全文
引用本文:唐焕君.ACEI联合醛固酮受体拮抗剂对高血压肾病患者Cys-C及尿微量蛋白的调节作用[J].药学实践杂志,2018,36(2):131~135
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作者单位
唐焕君 四川绵阳404医院, 四川 绵阳 621000 
基金项目:国家自然科学基金(81101797)
中文摘要:目的 探讨血管紧张素转化酶抑制剂(ACEI)联合醛固酮受体拮抗剂对高血压肾病患者血清半胱氨酸蛋白酶抑制剂C(Cys-C)及尿微量蛋白的调节作用。方法 将患者随机分为两组,两组均给予盐酸贝那普利,试验组在ACEI的基础上给予螺内酯治疗。治疗后检测两组血压、肾功能、24 h尿蛋白、Cys-C、肾小球滤过率(GFR)、尿微量蛋白,及GFR与Cys-C及尿微量蛋白的相关性。结果 经治疗,两组患者血压差异无统计学意义(P>0.05);试验组肾功能明显优于对照组,24 h蛋白尿低于对照组(P<0.05);试验组GFR水平明显高于对照组,Cys-C与尿微量蛋白明显低于对照组(P<0.05);GFR与Cys-C及尿微量蛋白呈负相关。结论 ACEI联合醛固酮受体拮抗剂可以改善患者肾功能,减少24 h血尿,治疗后伴随着Cys-C及尿微量蛋白的降低,GFR的滤过能力明显提升。
中文关键词:血管紧张素转化酶抑制剂  醛固酮受体拮抗剂  高血压肾病  血清半胱氨酸蛋白酶抑制剂C  尿微量蛋白
 
Effects of combination therapy with ACEI and aldosterone receptor antagonist on Cys-C and urinary microprotein in patients with hypertensive nephropathy
Abstract:Objective To investigate the effects of combination therapy with ACEI and aldosterone receptor antagonist on Cys-C and urinary microprotein regulation. Methods Patients were randomly divided into two groups. The control group received benazepine hydrochloride only. The experimental group received benazepine and spironolactone treatment. The blood pressure, renal function, 24 h urinary protein, Cys-C, GFR, urinary microprotein and the correlation of GFR with Cys-C and urinary microprotein were recorded. Results There was no statistically significant difference between two groups in blood pressure (P>0.05). After treatment, the renal function of the experimental group was significantly improved compared to that of the control group. The 24 h urine protein, Cys-C and urinary microprotein were significantly lower in the experimental group than the control group (P<0.05). GFR was negatively correlated with Cys-C and urinary microprotein. Conclusion The combination therapy of ACEI and aldosterone receptor antagonist can improve renal function and reduce 24 h hematuria. GFR filtration ability was significantly improved with the reduction of Cys-C and urinary microprotein.
keywords:aldosterone receptor antagonist  hypertensive nephropathy  Cys-C  urinary microprotein
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