丹参酮ⅡA对脑缺血后炎性反应影响机制的研究进展
投稿时间:2017-08-24  修订日期:2017-10-11  点此下载全文
引用本文:冯晶晶,李铁军,章越凡.丹参酮ⅡA对脑缺血后炎性反应影响机制的研究进展[J].药学实践杂志,2018,36(2):108~111
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作者单位E-mail
冯晶晶 安徽中医药大学药学院, 安徽 合肥 230012  
李铁军 安徽中医药大学药学院, 安徽 合肥 230012
上海市浦东新区浦南医院药剂科, 上海 200125 
ltj204@163.com 
章越凡 第二军医大学药学院药理学教研室, 上海 200433  
基金项目:浦东新区卫生系统重要薄弱学科建设资助(PWZbr2017-16)
中文摘要:丹参酮ⅡA是从丹参中提取的一种菲醌类衍生物,是丹参发挥脑缺血损伤保护药理作用的主要活性成分之一。炎症在脑缺血发病机制中具有重要作用。近年来许多证据表明,免疫细胞、黏附分子、炎性介质等通过诱导或调控脑缺血时中枢神经系统内免疫应答参与发病过程。综述丹参酮ⅡA对脑缺血后炎性反应影响机制的研究进展,为丹参酮ⅡA的脑缺血保护作用机制研究提供新思路。
中文关键词:丹参酮ⅡA  脑缺血  炎性反应
 
Progress of tanshinone ⅡA on the mechanism of inflammatory response after cerebral ischemia
Abstract:Tanshinone ⅡA is a kind of phenanthraquinone derivatives derived from Salvia miltiorrhiza, which is one of the main active components of Danshen to play the protective role of cerebral ischemic injury. Inflammation plays an important role in the pathogenesis of cerebral ischemia. In recent years, much evidence shows that immune cells, adhesion molecules, inflammatory mediators have been involved in the pathogenesis of immune response in the central nervous system through induction or regulation of cerebral ischemia. In this paper, the research progress of mechanism of inflammatory response of tanshinone ⅡA after cerebral ischemia was reviewed, which provided a new idea for the study of the protective mechanism of tanshinone ⅡA in cerebral ischemia.
keywords:tanshinone ⅡA  cerebral ischemia  inflammatory response
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