核-壳结构的脂质-聚合物杂化纳米粒的研究进展
投稿时间:2017-02-15  修订日期:2017-12-28  点此下载全文
引用本文:刘丹,张军东,廉云飞,房秋雨,李娟.核-壳结构的脂质-聚合物杂化纳米粒的研究进展[J].药学实践杂志,2018,36(1):13~17
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作者单位E-mail
刘丹 中国药科大学药学院, 江苏 南京 211198  
张军东 上海昊海生物科技股份有限公司, 上海 201600  
廉云飞 上海昊海生物科技股份有限公司, 上海 201600  
房秋雨 上海昊海生物科技股份有限公司, 上海 201600  
李娟 中国药科大学药学院, 江苏 南京 211198 lijuancpu1@163.com 
中文摘要:核-壳结构的脂质-聚合物杂化纳米粒(CSLPHNs)是以具有生物可降解性的聚合物纳米粒为核,外层包覆单层或多层具有生物膜仿生性的脂质壳而形成,结合了纳米粒和脂质体的双重优点,具有粒径小、载药量高、生物相容性好及缓控释给药等优势,在药物递送系统中应用甚广。笔者在查阅近年国内外文献的基础上归纳了CSLPHNs的基本特性、制备方法及在眼部给药、肿瘤治疗及临床诊断成像中的最新研究进展。
中文关键词:核-壳结构  脂质-聚合物杂化纳米粒  药物递送系统  肿瘤靶向
 
Advances in the studies of core-shell-type lipid-polymer hybrid nanoparticles
Abstract:Core-shell-type lipid-polymer hybrid nanoparticles(CSLPHNs) are composed by a biodegradable polymeric core coated with single or multiple layers of biomimetic lipids, which combine the benefits of polymeric nanoparticles and liposomes. CSLPHNs have the advantages of small particle size, high drug loading, good biocompatibility and controlled release capability. It has wide applications as a novel drug delivery system. This review gives a brief introduction in characteristics, preparation methods and applications of CSLPHNs, specifically summarizes the developments in the fields of ophthalmic drug delivery, tumor therapy and medical diagnostic imaging.
keywords:core-shell structure  lipid-polymer hybrid nanoparticles  drug delivery system  tumor targeted
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