体外脂解模型在脂质制剂评价中的研究进展
投稿时间:2017-04-07  修订日期:2017-09-04  点此下载全文
引用本文:吴慧仪,龙晓英.体外脂解模型在脂质制剂评价中的研究进展[J].药学实践杂志,2017,35(6):481~484,489
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作者单位E-mail
吴慧仪 南方医科大学南方医院药剂科, 广东 广州 510515  
龙晓英 广东药科大学中药学院, 广东 广州 510006 longxy3156@163.com 
基金项目:国家自然科学基金资助项目(81373361);广东省自然基金资助项目(S2013020012980)
中文摘要:体外脂解模型能模拟体内胃肠道生理环境,较好地反映脂质制剂口服后在人体肠道的性质,是一种具有应用前景的筛选和评价口服脂质制剂的新方法。综述脂质制剂的特性、胃肠道消化过程、体外脂解模型的应用及脂解液表征方法的研究进展,为脂解模型在脂质制剂口服吸收机制及体内外相关性研究中的深入应用提供依据。
中文关键词:脂解模型  脂质制剂  胃肠道  体内外相关性
 
Research progress on in vitro lipolysis model for the evaluation of lipid formulations
Abstract:In vitro lipolysis model has become a new and promising technique to screen and evaluate oral lipid formulations. This model mimics the gastrointestinal tract environment and well reflects the fate of lipid formulations in GI tract after oral administration. This review summarizes the characteristics of lipid formulations, process of gastrointestinal digestion, applications of in vitro lipolysis model and methods for the characterization of the lipolysis process, which provides the basis for the research of oral absorption mechanism and in vivo-in vitro correlations of lipid formulations with lipolysis model.
keywords:lipolysis model  lipid formulation  gastrointestinal  in vivo-in vitro correlation
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