辣木叶和种子的提取及急性毒性评价
投稿时间:2016-03-15  最后修改时间:2017-04-20  点此下载全文
引用本文:陈艳,张梅,王金萍,杨锋.辣木叶和种子的提取及急性毒性评价[J].药学实践杂志,2017,35(4):334~336,370
摘要点击次数: 63
全文下载次数: 88
作者单位
陈艳 陆军总医院药理科, 北京 100700;解放军总医院基础医学研究所, 北京 100853 
张梅 陆军总医院药理科, 北京 100700 
王金萍 陆军总医院药理科, 北京 100700 
杨锋 陆军总医院药理科, 北京 100700 
中文摘要:目的 测试辣木叶和种子的急性毒性以及安全剂量范围。方法 参照《中药药理研究方法学》设计实验,确定中药新药的最大耐受量和急性毒性。结果 小鼠对辣木叶超微粉和辣木叶醇提物的最大耐受量分别为0.4 g/20 g、0.8 g/20 g,辣木叶超微粉和辣木叶醇提物的成人日剂量分别在10 g/50 kg、20 g/50 kg以下为安全剂量。结论 辣木叶为较安全的药食两用植物,其药理作用值得进一步研究。
中文关键词:辣木  超微粉化  急性毒性
 
The extraction and acute toxicity testing of Moringa oleifera leaves and seeds
Abstract:Objective To test the acute toxicity and determine the safe dose range of Moringa oleifera leaves and seeds. Methods Acute toxicity tests were performed based on the documented experimental designs in Research Methods of Pharmacology of Chinese Traditional Medicine. Results The maximum tolerated dose of the superfine powder and alcoholic-aqueous extract of Moringa oleifera leaves were 0.4 g/20 g and 0.8 g/20 g for mice. The safe dose for human is under or equal to 10 g/50 kg and 20 g/50 kg. Conclusion Moringa oleifera leaves were safe for medical and food use. The further research and development is warranted for this plant.
keywords:Moringa oleifera  superfine powder process  acute toxicity testing
查看全文  查看/发表评论  下载PDF阅读器
关闭

分享按钮