心脑血管疾病的治疗新策略:激活压力感受性反射
投稿时间:2016-12-26  最后修改时间:2017-03-20  点此下载全文
引用本文:张丽丽,刘爱军,陈磊,宋洪涛.心脑血管疾病的治疗新策略:激活压力感受性反射[J].药学实践杂志,2017,35(4):294~297,345
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作者单位E-mail
张丽丽 福州总医院药学科, 福建 福州 350025  
刘爱军 第二军医大学药学院药理学教研室, 上海 200433  
陈磊 福州总医院药学科, 福建 福州 350025  
宋洪涛 福州总医院药学科, 福建 福州 350025 sohoto@vip.163.com 
中文摘要:我国心脑血管疾病的发病人数和死亡人数持续升高,动脉压力感受性反射(arterial baroreflex, ABR)功能受损与许多心脑血管疾病(如高血压、心衰等)的发生、发展密切相关。美国CVRx公司研发的Barostim neoTM仪器可以实现慢性刺激颈动脉窦处的压力感受器,激活压力反射,从而降低血压和心率,用于治疗顽固性高血压、心衰、终末期肾损伤等疾病。其治疗疾病的主要机制是抑制交感神经系统和肾素-血管紧张素系统,增强迷走神经的活动,进而改善压力感受性反射敏感性(baroreflex sensitivity, BRS)和心率变异性,恢复关键脏器的结构和功能。
中文关键词:压力感受性反射激活疗法  心脑血管疾病  机制
 
New strategy for cardio-cerebrovascular diseases: baroreflex activation therapy
Abstract:The incident number and death toll of cardio-cerebrovascular diseases increase continuously in China. The impairment of arterial baroreflex (ABR) is closely related to the genesis and development of cardio-cerebrovascular diseases (such as hypertension and chronic heart failure). Barostim neoTM (by American CRVx. Inc) can reduce blood pressure and heart rate by electrically stimulating carotid sinus baroreceptors and activating baroreflex. Therefore, it can be used to treat resistant hypertension, heart failure and end-stage renal disease, etc. The mechanism of baroreflex activation therapy (BAT) includes inhibiting sympathetic nervous system and rennin-angiotensin system, and increasing the activity of vagus nerve. Thus it improves baroreflex sensitivity and heart rate variability, and restores the structure and function of key organs.
keywords:baroreflex activation therapy  cardio-cerebrovascular diseases  mechanism
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